1. Impact on the digestive system.

1.1 on experimental gastric ulcer: pepper water extract 5 and 10g/kg significantly anti-mouse flooding stress ulcer formation effect, and the ether extract only suppress tendencies. There pepper water extract 10g/kg mice indomethacin significantly inhibited ethanol-induced ulceration Singa, but inhibition rate (22%) is not high. 3.0ml/kg pepper ether extract significantly inhibited the formation of hydrochloric acid and ulcers in rats (P <0.01). 5g/kg pepper water extract can inhibit the formation of ulcers in the pylorus ligated rats.

1.2 impact of acute liver injury induced by carbon tetrachloride in rat serum GPT and GOT pepper water extract 5.0g/kg against carbon tetrachloride can increase the role of GPT (P <0.05 =, and a dose-dependent manner, But elevated GOT no antagonism.

1.3 impact on drug-induced diarrhea in mice: pepper ether extract 3.O and 6.0ml/kg mice against castor oil can be caused by diarrhea, the role appears not only fast, but also durable. Wherein the occurrence of diarrhea 3.0ml/kg group also delayed two hours (1.2 hours for the occurrence of the control group was 5/12 and 11/12, Japanese pepper extract 3.0ml/kg ether group was 0/12 and 5/12, P values ​​were <0.05). Pepper 5 or 10g/kg water extract of senna-induced diarrhea in mice confrontation role, the role of produce slow but persistent (P <0.05). 4 ink on mouse gastrointestinal propulsive movement mice fed 10g/kg pepper water extract can inhibit gastrointestinal propulsive motility, P <0.05.

2 on experimental thrombosis and coagulation system: the use of electrical stimulation-induced arterial wall in vivo experimental thrombosis and simultaneous determination of its effects on blood coagulation. The experimental results showed that: water extract of pepper and pepper under 10-20g/kg ether extract 0.3ml/kg dose significantly inhibited thrombosis in rats (P <0.01 and P <0.001 =, can significantly prolong experimental thrombosis time, suggesting a role in the prevention of thrombosis. has some anticoagulant effect of aqueous extract of pepper and ether extract 0.15-0.3ml/kg 10g/kg dose, aqueous extract of the anticoagulant effect is stronger than the ether extract. pepper antithrombotic, anticoagulant effect may be related to platelet function anticoagulant component related to vascular endothelial cells, because the pepper water extract of ADP and collagen-induced platelet aggregation significantly inhibited, the inhibition rate was 50.4%, 88.3%, respectively. This product contains a certain confrontation bergapten anticoagulant effect of heparin and hemostasis.

3 analgesic effect: water extract 5-10g/kg pepper and ether extract 3.0-6.0ml/kg of acetic acid-induced writhing in mice significantly inhibited the reaction, aqueous extract of P <0.05, ether extract matter 3.0ml/kg (P <0.05), ether extract 6.0ml/kg (P <0.01), which is more effective than the ether extract water extract strong dose-dependent manner.

4 inhibitory effect: This product dermatophytes 11 kinds of volatile oil and four deep fungal inhibition and have a certain role in the killing, one of the most sensitive to wool-like small spores and Trichophyton rubrum, MIC below 0.1HL/ml , MFC is 0.1HL/ml. Experiments confirmed Azone and dimethyl sulfoxide in the volatile oil can promote fungal cells into accelerated cell death.

5 deworming effect: pepper volatile oil contained in the insulation can Ascaris Ringer solution in severe poisoning.

Pepper pharmacological effects:

1. Impact on the digestive system.

1.1 on experimental gastric ulcer: pepper water extract 5 and 10g/kg significantly anti-mouse flooding stress ulcer formation effect, and the ether extract only suppress tendencies. There pepper water extract 10g/kg mice indomethacin significantly inhibited ethanol-induced ulceration Singa, but inhibition rate (22%) is not high. 3.0ml/kg pepper ether extract significantly inhibited the formation of hydrochloric acid and ulcers in rats (P <0.01). 5g/kg pepper water extract can inhibit the formation of ulcers in the pylorus ligated rats.

1.2 impact of acute liver injury induced by carbon tetrachloride in rat serum GPT and GOT pepper water extract 5.0g/kg against carbon tetrachloride can increase the role of GPT (P <0.05 =, and a dose-dependent manner, But elevated GOT no antagonism.

1.3 impact on drug-induced diarrhea in mice: pepper ether extract 3.O and 6.0ml/kg mice against castor oil can be caused by diarrhea, the role appears not only fast, but also durable. Wherein the occurrence of diarrhea 3.0ml/kg group also delayed two hours (1.2 hours for the occurrence of the control group was 5/12 and 11/12, Japanese pepper extract 3.0ml/kg ether group was 0/12 and 5/12, P values ​​were <0.05). Pepper 5 or 10g/kg water extract of senna-induced diarrhea in mice confrontation role, the role of produce slow but persistent (P <0.05). 4 ink on mouse gastrointestinal propulsive movement mice fed 10g/kg pepper water extract can inhibit gastrointestinal propulsive motility, P <0.05.

2 on experimental thrombosis and coagulation system: the use of electrical stimulation-induced arterial wall in vivo experimental thrombosis and simultaneous determination of its effects on blood coagulation. The experimental results showed that: water extract of pepper and pepper under 10-20g/kg ether extract 0.3ml/kg dose significantly inhibited thrombosis in rats (P <0.01 and P <0.001 =, can significantly prolong experimental thrombosis time, suggesting a role in the prevention of thrombosis. has some anticoagulant effect of aqueous extract of pepper and ether extract 0.15-0.3ml/kg 10g/kg dose, aqueous extract of the anticoagulant effect is stronger than the ether extract. pepper antithrombotic, anticoagulant effect may be related to platelet function anticoagulant component related to vascular endothelial cells, because the pepper water extract of ADP and collagen-induced platelet aggregation significantly inhibited, the inhibition rate was 50.4%, 88.3%, respectively. This product contains a certain confrontation bergapten anticoagulant effect of heparin and hemostasis.

3 analgesic effect: water extract 5-10g/kg pepper and ether extract 3.0-6.0ml/kg of acetic acid-induced writhing in mice significantly inhibited the reaction, aqueous extract of P <0.05, ether extract matter 3.0ml/kg (P <0.05), ether extract 6.0ml/kg (P <0.01), which is more effective than the ether extract water extract strong dose-dependent manner.

4 inhibitory effect: This product dermatophytes 11 kinds of volatile oil and four deep fungal inhibition and have a certain role in the killing, one of the most sensitive to wool-like small spores and Trichophyton rubrum, MIC below 0.1HL/ml , MFC is 0.1HL/ml. Experiments confirmed Azone and dimethyl sulfoxide in the volatile oil can promote fungal cells into accelerated cell death.

5 deworming effect: pepper volatile oil contained in the insulation can Ascaris Ringer solution in severe poisoning.

6 Other effects: This product contains alkali skimmianine have ephedrine-like effects, but the strength is weak, can increase blood pressure in anesthetized cats, enhance haw contraction, strengthening the role of adrenaline on blood pressure and uterine strengthen cat or rabbit The reign of uterine contractions, inhibiting intestinal contraction and dilation of coronary blood vessels, improving striated muscle tension, strengthen the spinal reflex excitability. There is a strong antibacterial effect.